S-Adenosyl methionine is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. Although these anabolic reactions occur throughout the body, most SAM-e is produced and consumed in the liver. More than 40 methyl transfers from SAM-e are known, to various substrates such as nucleic acids, proteins, lipids and secondary metabolites. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase.

Indications:

⇒ Chronic liver disease
⇒ Depression
⇒ Fibromyalgia
⇒ As a dietary supplement for the support of bone and joint health, as well as mood and emotional well being.

Mechanism of action:

S-adenosylmethionine is an intermediate metabolite of methionine. Its involvement in methylation assists in cellular growth and repair, maintains the phospho-bilipid layer in cell membranes. It also helps in the maintenance of the action of several hormones and neurotransmitters that affect mood. Highest concentration are found in the brain and the liver. S-Adenosylmethionine (SAMe) is a natural substance present in the cells of the body. It is a direct metabolite of the essential amino acid L-methionine. SAMe plays a crucial biochemical role in the body by donating a one-carbon methyl group in a process called transmethylation. SAMe, formed from the reaction of L-methionine and adenosine triphosphate catalyzed by the enzyme S-adenosylmethionine synthetase, is the methyl-group donor in the biosynthesis of both DNA and RNA nucleic acids, phospholipids, proteins, epinephrine, melatonin, creatine and other molecules.

S-Adenosylmethionine is absorbed from the small intestine following oral intake. As absorption is affected by food, it is best to take on an empty stomach. Significant first-pass metabolism in the liver. Approximately 50% of S-Adenosylmethionine (SAMe) is metabolized in the liver. SAMe is metabolized to S-adenosylhomocysteine, which is then metabolized to homocysteine. Homocysteine can either be metabolized to cystathionine and then cysteine or to methionine. The cofactor in the metabolism of homocysteine to cysteine is vitamin B6. Cofactors for the metabolism of homocysteine to methionine are folic acid, vitamin B12 and betaine.

Side Effects:

The product is possible safe for most adults. There is no disadvantage associated with the product if taken under the recommended usage however headache, dizziness, nausea, abdominal distention and sleep problem may occur in some patients. If more severe side effects appear, immediately discontinue the use.

Contraindication:

⇒ Renal and hepatic impairment
⇒ Do not consume alcohol.

S-Adenosyl-L-Methionine can interact with the following drugs:
⇒ Dextromethorphan
⇒ Medications for depression (Antidepressant drugs)
⇒ Tramadol

Warning & Precaution:

⇒ Do not exceed the recommended dose
⇒ Keep out of reach of children